| date | stage | club1 | club2 | goals | |
| 1980-09-17 | Round_1 | AZ_Alkmaar(Netherlands) | Red_Boys_Differdange(Luxembourg) | 6 | 0 | - |
| 1980-09-17 | Round_1 | IA_Akranes(Iceland) | 1.FC_Koln(Germany) | 0 | 4 | - |
| 1980-09-17 | Round_1 | Sliema_Wanderers(Malta) | FC_Barcelona(Spain) | 0 | 2 | - |
| 1980-09-17 | Round_1 | Ujpest_Dozsa(Hungary) | Real_Sociedad(Spain) | 1 | 1 | - |
| 1980-09-17 | Round_1 | Arges_Pitesti(Romania) | FC_Utrecht(Netherlands) | 0 | 0 | - |
| 1980-09-17 | Round_1 | Ballymena_United(Northern Ireland) | FC_Vorwarts_Frankfurt(East Germany) | 2 | 1 | - |
| 1980-09-17 | Round_1 | Bohemians_Praha(Czechoslovakia) | Sporting_Gijon(Spain) | 3 | 1 | - |
| 1980-09-17 | Round_1 | Dynamo_Dresden(East Germany) | Napredak_Krusevac(Yugoslavia) | 1 | 0 | - |
| 1980-09-17 | Round_1 | IF_Elfsborg(Sweden) | St.Mirren(Scotland) | 1 | 2 | - |
| 1980-09-17 | Round_1 | Grasshoppers_Zurich(Switzerland) | KB_Kobenhavn(Denmark) | 3 | 1 | - |
| 1980-09-17 | Round_1 | Hamburger_SV(Germany) | FK_Sarajevo(Yugoslavia) | 4 | 2 | - |
| 1980-09-17 | Round_1 | Ipswich_Town(England) | Aris_Thessaloniki(Greece) | 5 | 1 | - |
| 1980-09-17 | Round_1 | Juventus(Italy) | Panathinaikos(Greece) | 4 | 0 | - |
| 1980-09-17 | Round_1 | 1.FC_Kaiserslautern(Germany) | Anderlecht(Belgium) | 1 | 0 | - |
| 1980-09-17 | Round_1 | Dynamo_Kiev(Soviet Union) | Levski-Spartak_Sofia(Bulgaria) | 1 | 1 | - |
| 1980-09-17 | Round_1 | PSV_Eindhoven(Netherlands) | Wolverhampton_Wanderers(England) | 3 | 1 | - |
| 1980-09-17 | Round_1 | KuPS_Kuopio(Finland) | AS_Saint-Etienne(France) | 0 | 7 | - |
| 1980-09-17 | Round_1 | LASK_Linz(Austria) | Radnicki_Nis(Yugoslavia) | 1 | 2 | - |
| 1980-09-17 | Round_1 | KSC_Lokeren(Belgium) | Dinamo_Moscow(Soviet Union) | 1 | 1 | - |
| 1980-09-17 | Round_1 | 1.FC_Magdeburg(East Germany) | Moss_FK(Norway) | 2 | 1 | - |
| 1980-09-17 | Round_1 | Manchester_United(England) | Widzew_Lodz(Poland) | 1 | 1 | - |
| 1980-09-17 | Round_1 | FC_Porto(Portugal) | Dundalk(Ireland) | 1 | 0 | - |